Dr Maria Dermit

Maria joined Mardakheh's lab in April 2017 as a postdoctoral researcher. She studied the relationship between RNA localisation and protein expression in mammalian cells. Synthesis of proteins from mRNA is not a 1 to 1 process, and there are many biochemical processes that impact on protein translation. One of them is dynamic movement of transcripts within the cellular milieu. During her time in Mardakheh's lab, Maria used multi-omics approaches to assess how RNA localisation is dysregulated in cancer cells via action of different RBPs, in order to promote a malignant phenotype. Maria's work has been published in Developmental Cell (https://doi.org/10.1016/j.devcel.2020.10.006and STAR Protocols (https://doi.org/10.1016/j.xpro.2021.100462).

Maria moved to the biotech sector in June 2021. She currently works for bit.bio in Cambridge, UK.

Dr Muhammad Syhami Azman

Syahmi joined Mardakheh lab in May 2017 as an MSc student, and continued to stay on in the lab as a PhD student afterwards. In his PhD, Syahmi studied how KRAS oncogene post-transcriptionally modulates gene expression in Pancreatic Ductal Adenocarcinoma (PDAC), via regulating the activity of specific RBPs. Syahmi specifically revealed that many RBPs involved in ribosome biogenesis are activated downstream of KRAS in PDAC. For one of these RBPs, the nucleolar protein Nucleolin, the RNA binding activity is specifically increased via phosphorylation downstream of RAS. Syhami went on to show that this phosphorylation could drive rRNA synthesis and ribosome biogenesis in PDAC, and this could be therapeutically exploited to inhibit tumour growth in vivo. You can find out more about Syahmi's work in our recent preprint: https://www.biorxiv.org/content/10.1101/2021.12.16.472890v1

Syahmi successfully completed his PhD in March 2022.

Dr Atiya Sarmin

Atiya is a final year PhD student at the Blizzard Institute, Queen Mary University of London. She completed a rotation project in the Mardakheh lab in the 1st year of her MRC DTP PhD programme programme in 2018.  During her project, Atyia worked to optimise a quantitative immunopeptidomics pipeline for analysis of tumour antigens. She then went on to the Blizzard Institute for her PhD project on 'Developing Advanced Models of Wound Healing and Inflammation using 3D Bioprinting' in Oct 2018. 

Atiya successfully completed her PhD project in January 2022.