Dr Maria Dermit
Dr Muhammad Syhami Azman
Syahmi joined Mardakheh lab in May 2017 as an MSc student, and continued to stay on in the lab as a PhD student afterwards. In his PhD, Syahmi studied how KRAS oncogene post-transcriptionally modulates gene expression in Pancreatic Ductal Adenocarcinoma (PDAC), via regulating the activity of specific RBPs. Syahmi specifically revealed that many RBPs involved in ribosome biogenesis are activated downstream of KRAS in PDAC. For one of these RBPs, the nucleolar protein Nucleolin, the RNA binding activity is specifically increased via phosphorylation downstream of RAS. Syhami went on to show that this phosphorylation could drive rRNA synthesis and ribosome biogenesis in PDAC, and this could be therapeutically exploited to inhibit tumour growth in vivo. You can find out more about Syahmi's work in our recent preprint: https://www.biorxiv.org/content/10.1101/2021.12.16.472890v1
Syahmi successfully completed his PhD in March 2022.
Atiya is a final year PhD student at the Blizzard Institute, Queen Mary University of London. She completed a rotation project in the Mardakheh lab in the 1st year of her MRC DTP PhD programme programme in 2018. During her project, Atyia worked to optimise a quantitative immunopeptidomics pipeline for analysis of tumour antigens. She then went on to the Blizzard Institute for her PhD project on 'Developing Advanced Models of Wound Healing and Inflammation using 3D Bioprinting' in Oct 2018.
Atiya successfully completed her PhD project in January 2022.